Synthesis and Structure–Activity Evaluation of Isatin-β-thiosemicarbazones with Improved Selective Activity toward Multidrug-Resistant Cells Expressing P-Glycoprotein-Reference-Cited by-同舟云学术

Synthesis and Structure–Activity Evaluation of Isatin-β-thiosemicarbazones with Improved Selective Activity toward Multidrug-Resistant Cells Expressing P-Glycoprotein

Published:2011-08-01 Issue:16 Volume:54 Page:5878-5889
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hall Matthew D.¹,Brimacombe Kyle R.¹,Varonka Matthew S.²,Pluchino Kristen M.¹,Monda Julie K.¹,Li Jiayang³,Walsh Martin J.⁴,Boxer Matthew B.⁴,Warren Timothy H.²,Fales Henry M.³,Gottesman Michael M.¹

Affiliation:

1. Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States

2. Department of Chemistry, Georgetown University, Box 571227, Washington, D.C. 20057, United States

3. Laboratory of Applied Mass Spectrometry, National Heart, Lung & Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, United States

4. NIH Chemical Genomics Center, NIH Center for Translational Therapeutics, National Institutes of Health, 9800 Medical Center Drive, MSC 3370, Bethesda, Maryland 20892, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm2006047

Reference48 articles.

1. Targeting multidrug resistance in cancer

2. Multidrug resistance in cancer: role of ATP–dependent transporters

3. Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor

4. Collateral Sensitivity of Multidrug-Resistant Cells to the Orphan Drug Tiopronin

5. The Selectivity of Austocystin D Arises from Cell-Line-Specific Drug Activation by Cytochrome P450 Enzymes

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