Novel isatin–triazole based thiosemicarbazones as potential anticancer agents: synthesis, DFT and molecular docking studies-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Novel isatin–triazole based thiosemicarbazones as potential anticancer agents: synthesis, DFT and molecular docking studies

Published:2024 Issue:20 Volume:14 Page:14051-14067
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Mushtaq Alia¹,Asif Rabbia¹,Humayun Waqar Ahmed²,Naseer Muhammad Moazzam¹^ORCID

Affiliation:

1. Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan

2. Department of Medical Oncology & Radiotherapy, King Edward Medical University, Lahore 54000, Pakistan

Abstract

Synthesis of mono- and bis-thiosemicarbazones 4a–h and 5a–h of isatin–triazole hybrids 3a and 3b in turn accessed via CuAAC, their DFT studies and potential as phosphoinositide 3-kinase (PI3K) inhibitors has been evaluated in this study.

Funder

Quaid-i-Azam University

The World Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA01937G

Reference109 articles.

1. Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets

2. Arylglyoxals in Synthesis of Heterocyclic Compounds

3. Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens

4. Rational structural modification of the isatin scaffold to develop new and potent antimicrobial agents targeting bacterial peptidoglycan glycosyltransferase

5. Synthesis and evaluation of the biological activity of N′-[2-oxo-1,2 dihydro-3H-indol-3-ylidene] benzohydrazides as potential anticancer agents

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP