Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens-Reference-Cited by-同舟云学术

Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens

Published:2022 Issue:48 Volume:12 Page:31466-31477
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Al-Warhi Tarfah¹,Elimam Diaaeldin M.²³,Elsayed Zainab M.⁴,Abdel-Aziz Marwa M.⁵,Maklad Raed M.⁶^ORCID,Al-Karmalawy Ahmed A.⁷^ORCID,Afarinkia Kamyar⁸^ORCID,Abourehab Mohammed A. S.⁹,Abdel-Aziz Hatem A.¹⁰,Eldehna Wagdy M.⁶¹¹^ORCID

Affiliation:

1. Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia

2. Department of Pharmacognosy, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt

3. School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK

4. Scientific Research and Innovation Support Unit, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt

5. The Regional Center for Mycology & Biotechnology, Al-Azhar University, Cairo, Egypt

6. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt

7. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza, 12566, Egypt

8. Institute of Cancer Therapeutics, University of Bradford, Bradford, BD7 1DP, UK

9. Department of Pharmaceutics, Faculty of Pharmacy, Umm Al-Qura University, Makkah, 21955, Saudi Arabia

10. Department of Applied Organic Chemistry, National Research Center, P.O. Box 12622, Dokki, Giza, Egypt

11. School of Biotechnology, Badr University in Cairo, Badr City, 11829, Egypt

Abstract

As promising antimicrobials against MDR pathogens, two novel series of isatin thiazolyl-pyrazoline conjugates were developed. Compounds 9f and 10h were the most effective against the tested MDR strains.

Funder

Umm Al-Qura University

Princess Nourah Bint Abdulrahman University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA04385H

Reference46 articles.

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3. Multidrug-Resistant Bacteria in the Community

4. J.O’Neill , Antimicrobial Resistance: Tackling a Crisis for the Health and Wealth of Nations: December 2014, Review on antimicrobial resistance , 2014

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