Discovery and Characterization of 4‘-(2-Furyl)-N-pyridin-3-yl-4,5‘-bipyrimidin-2‘-amine (LAS38096), a Potent, Selective, and Efficacious A2B Adenosine Receptor Antagonist-Reference-Cited by-同舟云学术

Discovery and Characterization of 4‘-(2-Furyl)-N-pyridin-3-yl-4,5‘-bipyrimidin-2‘-amine (LAS38096), a Potent, Selective, and Efficacious A2B Adenosine Receptor Antagonist

Published:2007-05-01 Issue:11 Volume:50 Page:2732-2736
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Vidal Bernat¹,Nueda Arsenio¹,Esteve Cristina¹,Domenech Teresa¹,Benito Sonia¹,Reinoso Raquel F.¹,Pont Mercè¹,Calbet Marta¹,López Rosa¹,Cadavid María Isabel¹,Loza María Isabel¹,Cárdenas Álvaro¹,Godessart Núria¹,Beleta Jorge¹,Warrellow Graham¹,Ryder Hamish¹

Affiliation:

1. Almirall Research Center, Almirall, Ctra. Laureà Miró 408, E-08980 St. Feliu de Llobregat, Barcelona, Spain, and Departamento de Farmacología, Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm061333v

Reference31 articles.

1. Adenosine in Tissue Protection and Tissue Regeneration: TABLE 1

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4. Adenosine A2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma.

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