3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure–Activity Relationship Studies, and Enantiospecific Recognition-Reference-Cited by-同舟云学术

3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure–Activity Relationship Studies, and Enantiospecific Recognition

Published:2020-12-29 Issue:1 Volume:64 Page:458-480
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Majellaro María¹²,Jespers Willem³^ORCID,Crespo Abel¹²,Núñez María J.⁴,Novio Silvia⁴,Azuaje Jhonny¹²,Prieto-Díaz Rubén¹²^ORCID,Gioé Claudia¹²,Alispahic Belma³,Brea José⁵,Loza María I.⁵,Freire-Garabal Manuel⁴,Garcia-Santiago Carlota⁴,Rodríguez-García Carlos¹²,García-Mera Xerardo²,Caamaño Olga²,Fernandez-Masaguer Christian²,Sardina Javier F.¹^ORCID,Stefanachi Angela⁶^ORCID,El Maatougui Abdelaziz¹²,Mallo-Abreu Ana¹²,Åqvist Johan³^ORCID,Gutiérrez-de-Terán Hugo³^ORCID,Sotelo Eddy¹²^ORCID

Affiliation:

1. Centro Singular de Investigación en Química Biolóxica y Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain

2. Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain

3. Department of Cell and Molecular Biology, Uppsala University, SE-75124 Uppsala, Sweden

4. SNL, Departamento de Farmacología, Facultade de Medicina, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain

5. Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain

6. Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari ALDO MORO, via Orabona 4, 70125 Bari, Italy

Funder

Vetenskapsr?det

Uppsala Universitet

European Regional Development Fund

Xunta de Galicia

Conseller?a de Cultura, Educaci?n e Ordenaci?n Universitaria, Xunta de Galicia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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