Peptide-Based In Vitro Assay for the Detection of Reactive Metabolites-Reference-Cited by-同舟云学术

Peptide-Based In Vitro Assay for the Detection of Reactive Metabolites

Published:2008-03-28 Issue:4 Volume:21 Page:859-868
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Mitchell Michael D.¹,Elrick Mollisa M.¹,Walgren Jennie L.¹,Mueller Richard A.¹,Morris Dale L.¹,Thompson David C.¹

Affiliation:

1. Drug Safety Research and Development, Pfizer Global Research and Development, 700 Chesterfield Parkway West T1A, Chesterfield, Missouri 63017, and ChemGate, Inc., 562 Stonegate Terrace, Glencoe, Illinois 60022

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx700344m

Reference54 articles.

1. Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective

2. New Concepts in Immunology Relevant to Idiosyncratic Drug Reactions: The “Danger Hypothesis” and Innate Immune System

3. Role of Metabolism in Drug-Induced Idiosyncratic Hepatotoxicity

4. Drug−Protein Adducts: An Industry Perspective on Minimizing the Potential for Drug Bioactivation in Drug Discovery and Development

5. Rapid detection and characterization of minor reactive metabolites using stable-isotope trapping in combination with tandem mass spectrometry

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