Metabolic activation and drug-induced liver injury:in vitroapproaches for the safety risk assessment of new drugs
Author:
Affiliation:
1. Unidad de Hepatología Experimental; Instituto de Investigación Sanitaria La Fe (IIS La Fe); Valencia Spain
2. CIBEREHD; FIS; Spain
3. Departamento de Bioquímica y Biología Molecular, Facultad de Medicina; Universidad de Valencia; Spain
Funder
Instituto de Salud Carlos III of the Spanish Ministry of Economy and Competitiveness
ALIVE Foundation
Publisher
Wiley
Subject
Toxicology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/jat.3277/fullpdf
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3. Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells;Aninat;Drug Metab. Dispos.,2006
4. An in vitro assay to assess transporter-based cholestatic hepatotoxicity using sandwich-cultured rat hepatocytes;Ansede;Drug Metab. Dispos.,2010
5. Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells;Antherieu;Hepatology,2013
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