Liabilities Associated with the Formation of “Hard” Electrophiles in Reactive Metabolite Trapping Screens-Reference-Cited by-同舟云学术

Liabilities Associated with the Formation of “Hard” Electrophiles in Reactive Metabolite Trapping Screens

Published:2016-11-10 Issue:1 Volume:30 Page:220-238
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Kalgutkar Amit S.¹

Affiliation:

1. Pharmacokinetics, Dynamics, and Metabolism − New Chemical Entities, Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.6b00332

Reference163 articles.

1. Reactive Metabolite Trapping Screens and Potential Pitfalls: Bioactivation of a Homomorpholine and Formation of an Unstable Thiazolidine Adduct

2. Hard and soft acids and bases—the evolution of a chemical concept

3. Molecular Mechanisms of Aldehyde Toxicity: A Chemical Perspective

4. Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings

5. A Comprehensive Listing of Bioactivation Pathways of Organic Functional Groups

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