Reactive Metabolite Trapping Screens and Potential Pitfalls: Bioactivation of a Homomorpholine and Formation of an Unstable Thiazolidine Adduct
Author:
Affiliation:
1. DMPK Department, Alderley Park, AstraZeneca UK Ltd., Macclesfield, Cheshire SK10 4TG, United Kingdom
2. DMPK and Medicinal Chemistry Department, AstraZeneca R&D Montreal, St. Laurent, QC Canada H4S 1Z9
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/tx5000409
Reference23 articles.
1. Drug−Protein Adducts: An Industry Perspective on Minimizing the Potential for Drug Bioactivation in Drug Discovery and Development
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5. Metabolism of 5-hydroxytryptamine by brain synaptosomes and microsomes in the presence of cysteine and glutathione
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