Mechanism of inhibition of mammalian tumor and other thymidylate synthases by N4-hydroxy-dCMP, N4-hydroxy-5-fluoro-dCMP, and related analogs

Author:

Rode Wojciech,Zielinski Zbigniew,Dzik Jolanta M.,Kulikowski Tadeusz,Bretner Maria,Kierdaszuk Borys,Ciesla Joanna,Shugar David

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Reference37 articles.

1. Conformation of exocyclic amino groups in purines and pyrimidines: crystal structure and conformation of 1-methyl-N4-hydroxycytosine hydrochloride

2. 5-(.alpha.-Bromoacetyl)-2'-deoxyuridine 5'-phosphate: an affinity label for thymidylate synthetase

3. Ciesla, J., Rode, W., Kempny, M., Pawelczak, K. & Rzeszotarska, B. (1990) in Chemistry and Biology of Pteridines1989. Pteridines and Folic Acid Derivatives (Curtius,H.Ch., Ghisla, S„ & Blau, N., Eds.) pp829-832, Walter de Gruyter, New York.

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