Phosphorylation of thymidylate synthase affects slow-binding inhibition by 5-fluoro-dUMP and N4-hydroxy-dCMP
Author:
Affiliation:
1. Nencki Institute of Experimental Biology
2. 02-093 Warszawa
3. Poland
4. Department of Chemistry
5. Rzeszów University of Technology
6. 35-959 Rzeszów
7. Institute of Experimental Physics
8. Warsaw University
9. Warszawa
Abstract
Thymidylate synthase protein phosphorylation affects inhibition of the enzyme, potentially influencing pathogen drug sensitivity.
Publisher
Royal Society of Chemistry (RSC)
Subject
Molecular Biology,Biotechnology
Link
http://pubs.rsc.org/en/content/articlepdf/2016/MB/C6MB00026F
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1. Targeting thymidylate synthase in colorectal cancer: critical re-evaluation and emerging therapeutic role of raltitrexed
2. Thymidylate synthase as a chemotherapeutic drug target: Where are we after fifty years?
3. Standing the test of time: targeting thymidylate biosynthesis in cancer therapy
4. Inside the biochemical pathways of thymidylate synthase perturbed by anticancer drugs: Novel strategies to overcome cancer chemoresistance
5. THE CATALYTIC MECHANISM AND STRUCTURE OF THYMIDYLATE SYNTHASE
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