Thymidylate synthase-catalyzed, tetrahydrofolate-dependent self-inactivation by 5-FdUMP

Author:

Sobich Justyna,Prokopowicz Małgorzata,Maj Piotr,Wilk Piotr,Zieliński Zbigniew,Frączyk Tomasz,Rode WojciechORCID

Funder

National Science Center, Poland

Publisher

Elsevier BV

Subject

Molecular Biology,Biochemistry,Biophysics

Reference27 articles.

1. The catalytic mechanism and structure of thymidylate synthase;Carreras;Annu. Rev. Biochem.,1995

2. Molecular mechanism of thymidylate synthase-catalyzed reaction and interaction of the enzyme with 2- and/or 4-substituted analogues of dUMP and 5-fluoro-dUMP;Rode;Acta Biochim. Pol.,1996

3. Folate-dependent thymidylate-forming enzymes: parallels between DNA and RNA metabolic enzymes and evolutionary implications;Myllykallio,2009

4. Thymidylate synthase: a critical target for cancer chemotherapy;Rose;Clin. Colorectal Cancer,2002

5. Thymidylate synthase as a chemotherapeutic drug target: where are we after fifty years?;Berger;Cancer Biol. Ther.,2006

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