Systematic Approach to Organizing Structural Alerts for Reactive Metabolite Formation from Potential Drugs
Author:
Affiliation:
1. Awametox AB, Lilldalsvägen 17 A, SE-14461 Rönninge, Sweden
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.8b00046
Reference123 articles.
1. Dose-dependent acute liver injury with hypersensitivity features in humans due to a novel microsomal prostaglandin E synthase 1 inhibitor
2. Metabolites in Safety Testing (MIST): Considerations of Mechanisms of Toxicity with Dose, Abundance, and Duration of Treatment
3. Idiosyncratic drug reactions: a mechanistic evaluation of risk factors.
4. How Reactive Metabolites Induce an Immune Response That Sometimes Leads to an Idiosyncratic Drug Reaction
5. Mechanism-Based Inactivation of Human Cytochromes P450s: Experimental Characterization, Reactive Intermediates, and Clinical Implications
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