Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells-Reference-Cited by-同舟云学术

Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells

Published:2023-08-24 Issue:17 Volume:63 Page:5433-5445
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Béquignon Olivier J. M.¹^ORCID,Gómez-Tamayo Jose C.²,Lenselink Eelke B.¹^ORCID,Wink Steven¹,Hiemstra Steven¹,Lam Chi Chung¹,Gadaleta Domenico³^ORCID,Roncaglioni Alessandra³,Norinder Ulf⁴,Water Bob van de¹^ORCID,Pastor Manuel²^ORCID,van Westen Gerard J. P.¹^ORCID

Affiliation:

1. Leiden Academic Centre for Drug Research, Leiden University, Wassenaarseweg 76, 2333 AL Leiden, The Netherlands

2. Research Programme on Biomedical Informatics (GRIB), Department of Medicine and Life Sciences, Hospital del Mar Medical Research Institute, Universitat Pompeu Fabra, Carrer del Dr. Aiguader 88, 08002 Barcelona, Spain

3. Laboratory of Environmental Chemistry and Toxicology, Department of Environmental Health Sciences, IRCCS─Istituto di Ricerche Farmacologiche Mario Negri, Via la Masa 19, 20156 Milano, Italy

4. MTM Research Centre, School of Science and Technology, Örebro University, SE-70182 Örebro, Sweden

Funder

Innovative Medicines Initiative

H2020 Health

European Federation of Pharmaceutical Industries and Associations

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.3c00220

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4. An Expert System Approach to the Assessment of Hepatotoxic Potential

5. A New Structure-Activity Relationship (SAR) Model for Predicting Drug-Induced Liver Injury, Based on Statistical and Expert-Based Structural Alerts