Dose-dependent acute liver injury with hypersensitivity features in humans due to a novel microsomal prostaglandin E synthase 1 inhibitor
Author:
Affiliation:
1. Eli Lilly and Company; Indianapolis Indiana USA
2. Covance Clinical Research Unit; Dallas Texas USA
3. Eli Lilly Japan K.K.; Kobe Japan
4. Leslie Dan Faculty of Pharmacy; University of Toronto; Toronto Ontario Canada
Funder
Eli Lilly and Company
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/bcp.13423/fullpdf
Reference26 articles.
1. Nonsteroidal anti-inflammatory drugs and hepatic toxicity: a systematic review of randomized controlled trials in arthritis patients;Rostom;Clin Gastroenterol Hepatol,2005
2. Pharmacokinetic-pharmacodynamic correlations and biomarkers in the development of COX-2 inhibitors;Huntjens;Rheumatology (Oxford),2005
3. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis;Warner;Proc Natl Acad Sci U S A,1999
4. Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2;McAdam;Proc Natl Acad Sci U S A,1999
5. Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1;Kamei;J Biol Chem,2004
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