Metabolites in Safety Testing (MIST): Considerations of Mechanisms of Toxicity with Dose, Abundance, and Duration of Treatment-Reference-Cited by-同舟云学术

Metabolites in Safety Testing (MIST): Considerations of Mechanisms of Toxicity with Dose, Abundance, and Duration of Treatment

Published:2009-01-23 Issue:2 Volume:22 Page:267-279
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Smith Dennis A.¹,Obach R. Scott¹

Affiliation:

1. Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., Sandwich, Kent, U.K., and Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., Groton, Connecticut

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx800415j

Reference96 articles.

1. Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective

2. SEEING THROUGH THE MIST: ABUNDANCE VERSUS PERCENTAGE. COMMENTARY ON METABOLITES IN SAFETY TESTING

3. Metabolites and Safety: What Are the Concerns, and How Should We Address Them?

4. Oxidative stress as a mechanism of teratogenesis

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