Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors
Author:
Affiliation:
1. Pfizer Worldwide Research & Development, Eastern Point Road, Groton, Connecticut 06340, United States
2. Peakdale Molecular Ltd, Peakdale Science Park, Sheffield Road, Chapel-en-le-Frith, High Peak, SK23 0PG, United Kingdom
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/jo3014808
Reference21 articles.
1. Disordered Lipid Metabolism and the Pathogenesis of Insulin Resistance
2. Acetyl-coenzyme A carboxylases: Versatile targets for drug discovery
3. Maximizing Lipophilic Efficiency: The Use of Free-Wilson Analysis in the Design of Inhibitors of Acetyl-CoA Carboxylase
4. Synthesis of 7-Oxo-dihydrospiro[indazole-5,4′-piperidine] Acetyl-CoA Carboxylase Inhibitors
5. Complementary α-alkylation approaches for a sterically hindered spiro[pyrazolopyranpiperidine]ketone
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