Synthesis of 7-Oxo-dihydrospiro[indazole-5,4′-piperidine] Acetyl-CoA Carboxylase Inhibitors-Reference-Cited by-同舟云学术

Synthesis of 7-Oxo-dihydrospiro[indazole-5,4′-piperidine] Acetyl-CoA Carboxylase Inhibitors

Published:2012-01-25 Issue:3 Volume:77 Page:1497-1506
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Bagley Scott W.¹,Southers James A.¹,Cabral Shawn¹,Rose Colin R.¹,Bernhardson David J.¹,Edmonds David J.¹,Polivkova Jana¹,Yang Xiaojing¹,Kung Daniel W.¹,Griffith David A.¹,Bader Scott J.¹

Affiliation:

1. Pfizer Worldwide Research & Development, Eastern Point Road, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo202377g

Reference34 articles.

1. Disordered Lipid Metabolism and the Pathogenesis of Insulin Resistance

2. Malonyl-CoA, a Key Signaling Molecule in Mammalian Cells

3. Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured Cells and in Experimental Animals

4. Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2

5. bCorbett, J. W.; Elliott, R. L.; Bell, A.Spiroketone acetyl-CoA carboxylase inhibitors. WO08065508; 2008.

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