Convergent Syntheses of Isomeric Imidazolospiroketones as Templates for Acetyl-CoA Carboxylase (ACC) Inhibitors
Author:
Affiliation:
1. Pfizer Medicine Design, Groton, Connecticut 06340, United States
2. Pfizer Medicine Design, Cambridge, Massachusetts 02139, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.joc.3c01374
Reference52 articles.
1. Recent Advances in Acetyl-CoA Carboxylase Inhibitors
2. Review of recent acetyl-CoA carboxylase inhibitor patents: mid-2007 – 2008
3. Malonyl-CoA, a Key Signaling Molecule in Mammalian Cells
4. Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured Cells and in Experimental Animals
5. GS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH)
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