Maximizing Lipophilic Efficiency: The Use of Free-Wilson Analysis in the Design of Inhibitors of Acetyl-CoA Carboxylase-Reference-Cited by-同舟云学术

Maximizing Lipophilic Efficiency: The Use of Free-Wilson Analysis in the Design of Inhibitors of Acetyl-CoA Carboxylase

Published:2012-01-11 Issue:2 Volume:55 Page:935-942
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Freeman-Cook Kevin D.¹,Amor Paul¹,Bader Scott¹,Buzon Leanne M.¹,Coffey Steven B.¹,Corbett Jeffrey W.¹,Dirico Kenneth J.¹,Doran Shawn D.¹,Elliott Richard L.¹,Esler William¹,Guzman-Perez Angel¹,Henegar Kevin E.¹,Houser Janet A.¹,Jones Christopher S.¹,Limberakis Chris¹,Loomis Katherine¹,McPherson Kirk¹,Murdande Sharad¹,Nelson Kendra L.¹,Phillion Dennis¹,Pierce Betsy S.¹,Song Wei¹,Sugarman Eliot¹,Tapley Susan¹,Tu Meihua¹,Zhao Zhengrong¹

Affiliation:

1. Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201503u

Reference21 articles.

1. World Health Organization fact sheets. http://www.who.int/mediacentre/factsheets/fs312/en/index.html(accessed July 18, 2011) .

2. Prevalence of Obesity, Diabetes, and Obesity-Related Health Risk Factors, 2001

3. Disordered Lipid Metabolism and the Pathogenesis of Insulin Resistance