Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor-Reference-Cited by-同舟云学术

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Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor

Published:2015-10-06 Issue:41 Volume:54 Page:6382-6391
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Wales Thomas E.¹,Hochrein James M.¹,Morgan Christopher R.¹,Emert-Sedlak Lori A.²,Smithgall Thomas E.²,Engen John R.¹

Affiliation:

1. Department of Chemistry & Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States

2. Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, United States

Funder

National Institute of Allergy and Infectious Diseases

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.5b00875

Reference42 articles.

1. Hematopoietic cell kinase (Hck) isoforms and phagocyte duties – From signaling and actin reorganization to migration and phagocytosis

2. Expression of a Src Family Kinase in Chronic Myelogenous Leukemia Cells Induces Resistance to Imatinib in a Kinase-dependent Manner

3. An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259

4. Src Family Kinases Phosphorylate the Bcr-Abl SH3-SH2 Region and Modulate Bcr-Abl Transforming Activity

5. A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo

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1. Structure–Activity Relationships of Natural and Semisynthetic Plecomacrolides Suggest Distinct Pathways for HIV-1 Immune Evasion and Vacuolar ATPase-Dependent Lysosomal Acidification;Journal of Medicinal Chemistry;2024-03-07

2. Computer-aided de novo design and optimization of novel potential inhibitors of HIV-1 Nef protein;Computational Biology and Chemistry;2023-06

3. Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor;Viruses;2022-09-13

4. Inhibitors of HIV-1 Nef: applications and developments for a practical cure;Virologie;2022-01-01

5. Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes;Journal of Biological Chemistry;2020-10

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