A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo-Reference-Cited by-同舟云学术

A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo

Published:2013-04-17 Issue:181 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Saito Yoriko¹,Yuki Hitomi²,Kuratani Mitsuo²,Hashizume Yoshinobu³,Takagi Shinsuke¹⁴,Honma Teruki²,Tanaka Akiko²,Shirouzu Mikako²,Mikuni Junko²,Handa Noriko²,Ogahara Ikuko¹,Sone Akiko¹,Najima Yuho¹,Tomabechi Yuri²,Wakiyama Motoaki²,Uchida Naoyuki⁴,Tomizawa-Murasawa Mariko¹,Kaneko Akiko¹,Tanaka Satoshi⁵,Suzuki Nahoko¹,Kajita Hiroshi¹,Aoki Yuki¹,Ohara Osamu⁶,Shultz Leonard D.⁷,Fukami Takehiro⁸,Goto Toshio⁸,Taniguchi Shuichi⁴,Yokoyama Shigeyuki²,Ishikawa Fumihiko¹

Affiliation:

1. Laboratory for Human Disease Models, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan.

2. RIKEN Systems and Structural Biology Center, Yokohama, Kanagawa 230-0045, Japan.

3. Drug Discovery Chemistry Platform Unit, RIKEN Center for Molecular Imaging Science, Wako, Saitama 351-0198, Japan.

4. Department of Hematology, Toranomon Hospital, Tokyo 105-8470, Japan.

5. Nippon Becton Dickinson Company, Tokyo 107-0052, Japan.

6. Laboratory for Immunogenomics, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan.

7. The Jackson Laboratory, Bar Harbor, ME 04609, USA.

8. RIKEN Program for Drug Discovery and Medical Technology Platforms, Yokohama, Kanagawa 230-0045, Japan.

Abstract

A pyrrolo-pyrimidine kinase inhibitor, RK-20449, eliminates chemotherapy-resistant human primary AML stem cells in vivo.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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