An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259-Reference-Cited by-同舟云学术

An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259

Published:2008-09-15 Issue:56 Volume:27 Page:7055-7069
ISSN:0950-9232
Container-title:Oncogene
language:en
Short-container-title:Oncogene

Author:

Pene-Dumitrescu T,Peterson L F,Donato N J,Smithgall T E

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Molecular Biology

Link

http://www.nature.com/articles/onc2008330.pdf

Reference70 articles.

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3. Bhatia R, Holtz M, Niu N, Gray R, Snyder DS, Sawyers CL et al. (2003). Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment. Blood 101: 4701–4707.

4. Bishop AC, Ubersax JA, Petsch DT, Matheos DP, Gray NS, Blethrow J et al. (2000). A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407: 395–401.

5. Blencke S, Ullrich A, Daub H . (2003). Mutation of threonine 766 in the epidermal growth factor receptor reveals a hotspot for resistance formation against selective tyrosine kinase inhibitors. J Biol Chem 278: 15435–15440.

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