Synthesis and Evaluation of Aminocyclopentitol Inhibitors of β-Glucosidases

Author:

Boss Olivier1,Leroy Emmanuel1,Blaser Adrian1,Reymond Jean-Louis1

Affiliation:

1. Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference19 articles.

1. Recent reviews:  (a) Bols, M.Acc. Chem. Res.1998,31, 1. (b) Heightman, T. D.; Vasella, A. T.Angew. Chem.1999,111, 795. (c) Davies, G.; Sinnott, M. L.; Withers, S. G. InComprehensive Biological Catalysis; Sinnott, M., Ed.; Academic Press:  London, 1998; pp 119−208.

2. Synthesis and Biological Activity of Natural Aminocyclopentitol Glycosidase Inhibitors:  Mannostatins, Trehazolin, Allosamidins, and Their Analogues

3. Anomer-Selective Inhibition of Glycosidases Using Aminocyclopentanols

4. Complete kinetic isotope effect description of transition states for acid-catalyzed hydrolyses of methyl .alpha.- and .beta.-glucopyranosides

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