Synthesis of hydroxymethyl analogues of mannostatin A and their evaluation as inhibitors of GH38 α-mannosidases-Reference-Cited by-同舟云学术

Synthesis of hydroxymethyl analogues of mannostatin A and their evaluation as inhibitors of GH38 α-mannosidases

Published:2021 Issue:30 Volume:45 Page:13539-13548
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Kalník Martin¹²³⁴⁵^ORCID,Zajičková Mária¹²³⁴⁵,Kóňa Juraj¹²³⁴⁵,Šesták Sergej¹²³⁴⁵,Moncoľ Ján⁶⁷⁸⁹⁵^ORCID,Koóš Miroslav¹²³⁴⁵,Bella Maroš¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Chemistry

2. Centre for Glycomics

3. Slovak Academy of Sciences

4. SK-845 38 Bratislava

5. Slovakia

6. Department of Inorganic Chemistry

7. Faculty of Chemical and Food Technology

8. Radlinského 9

9. SK-812 37 Bratislava

Abstract

Analogues of mannostatin A were synthesised and evaluated as inhibitors of GH38 α-mannosidases. Different regioselectivity of aziridine opening with sodium methanethiolate was observed and investigated by quantum mechanics calculations.

Funder

Agentúra na Podporu Výskumu a Vývoja

Vedecká Grantová Agentúra MŠVVaŠ SR a SAV

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D1NJ02351A

Reference53 articles.

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4. Design, Synthesis, and Biological Evaluation of N-Alkylated Deoxynojirimycin (DNJ) Derivatives for the Treatment of Dengue Virus Infection

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