Rational Modification of a Candidate Cancer Drug for Use Against Chagas Disease-Reference-Cited by-同舟云学术

Rational Modification of a Candidate Cancer Drug for Use Against Chagas Disease

Published:2009-02-24 Issue:6 Volume:52 Page:1639-1647
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kraus James M.¹,Verlinde Christophe L. M. J.¹,Karimi Mandana¹,Lepesheva Galina I.¹,Gelb Michael H.¹,Buckner Frederick S.¹

Affiliation:

1. Department of Chemistry, Department of Biochemistry, Department of Medicine, University of Washington, Seattle, Washington 98195-7185, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801313t

Reference31 articles.

1. The Protein Farnesyltransferase Inhibitor Tipifarnib as a New Lead for the Development of Drugs against Chagas Disease

2. Pharmacogenetics of tipifarnib (R115777) transport and metabolism in cancer patients

3. Phase I and Pharmacokinetic Study of Farnesyl Protein Transferase Inhibitor R115777 in Advanced Cancer

4. Activities of the Triazole Derivative SCH 56592 (Posaconazole) against Drug-Resistant Strains of the Protozoan Parasite Trypanosoma ( Schizotrypanum ) cruzi in Immunocompetent and Immunosuppressed Murine Hosts

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