The Protein Farnesyltransferase Inhibitor Tipifarnib as a New Lead for the Development of Drugs against Chagas Disease-Reference-Cited by-同舟云学术

The Protein Farnesyltransferase Inhibitor Tipifarnib as a New Lead for the Development of Drugs against Chagas Disease

Published:2005-07-22 Issue:17 Volume:48 Page:5415-5418
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hucke Oliver¹,Gelb Michael H.¹,Verlinde Christophe L. M. J.¹,Buckner Frederick S.¹

Affiliation:

1. Departments of Biochemistry, Chemistry, Biological Structure, Medicine, and Biomolecular Structure Center, University of Washington, Seattle, Washington 98195

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050441z

Reference17 articles.

1. Cloning, heterologous expression, and substrate specificities of protein farnesyltransferases from Trypanosoma cruzi and Leishmania major

2. Farnesyltransferase inhibitors

3. Comparative Protein Modelling by Satisfaction of Spatial Restraints

4. Crystal structure of cytochrome P450 14 -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors

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