Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors-Reference-Cited by-同舟云学术

Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors

Published:2023-01-10 Issue:2 Volume:14 Page:156-162
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Torrente Esther¹^ORCID,Fodale Valentina²,Ciammaichella Alina¹,Ferrigno Federica¹,Ontoria Jesus M.¹,Ponzi Simona¹,Rossetti Ilaria¹,Sferrazza Alessio¹,Amaudrut Jérôme³^ORCID,Missineo Antonino²,Esposito Simone¹,Palombo Simone¹,Nibbio Martina¹,Cerretani Mauro²,Bisbocci Monica²,Cellucci Antonella¹,di Marco Annalise¹,Alli Cristina²,Pucci Vincenzo¹,Toniatti Carlo¹²,Petrocchi Alessia¹

Affiliation:

1. Department of Drug Discovery IRBM S.p.A., Pomezia, Rome 00071, Italy

2. Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Rome 00071, Italy

3. Department of Drug Discovery - External consultant, IRBM S.p.A., Pomezia, Rome, 00071, Italy

Funder

Collezione Nazionale di Composti Chimici e Centro di screening

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00454

Reference25 articles.

1. An Shp2/SFK/Ras/Erk Signaling Pathway Controls Trophoblast Stem Cell Survival

2. Molecular Mechanism for a Role of SHP2 in Epidermal Growth Factor Receptor Signaling

3. The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors

4. SHP-2 Regulates SOCS-1-mediated Janus Kinase-2 Ubiquitination/Degradation Downstream of the Prolactin Receptor

5. The tyrosine phosphatase SHP-2 regulates differentiation and apoptosis of individual primary T lymphocytes

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