Investigation of the Bioactive Conformation of Histamine H3 Receptor Antagonists by the Cyclopropylic Strain-Based Conformational Restriction Strategy-Reference-Cited by-同舟云学术

Investigation of the Bioactive Conformation of Histamine H3 Receptor Antagonists by the Cyclopropylic Strain-Based Conformational Restriction Strategy

Published:2010-04-16 Issue:9 Volume:53 Page:3585-3593
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Watanabe Mizuki¹,Hirokawa Takatsugu²,Kobayashi Takaaki¹,Yoshida Akira³,Ito Yoshihiko³,Yamada Shizuo³,Orimoto Naoki⁴,Yamasaki Yasundo⁴,Arisawa Mitsuhiro¹,Shuto Satoshi¹

Affiliation:

1. Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan

2. Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Aomi, Koutou-ku, Tokyo 135-0064, Japan

3. Department of Pharmacokinetics and Pharmacodynammics and Global Center of Excellence (COE), School of Pharmaceutical Sciences, University of Shizuoka, Yada, Shizuoka 422-8526, Japan

4. Hanno Research Center, Taiho Pharmaceutical Co. Ltd., Misugidai, Hanno 357-8527, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901848b

Reference47 articles.

1. Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor

2. The histamine H3 receptor: from gene cloning to H3 receptor drugs

3. Keynote review: Histamine H3 receptor antagonists reach out for the clinic

4. Histamine H3 Receptor Antagonists: Preclinical Promise for Treating Obesity and Cognitive Disorders

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