Synthesis and biological activity of cyclopropyl Δ7-dafachronic acids as DAF-12 receptor ligands-Reference-Cited by-同舟云学术

Synthesis and biological activity of cyclopropyl Δ7-dafachronic acids as DAF-12 receptor ligands

Published:2021 Issue: Volume: Page:
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Mancino Valentina¹²³⁴⁵,Ceccarelli Giada¹²³⁴,Carotti Andrea¹²³⁴^ORCID,Goracci Laura⁶⁷²³⁴^ORCID,Sardella Roccaldo¹²³⁴,Passeri Daniela⁵³⁴,Pellicciari Roberto⁵³⁴,Gioiello Antimo¹²³⁴^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences

2. University of Perugia

3. Perugia

4. Italy

5. TES Pharma S.r.l.

6. Department of Chemistry

7. Biology and Biotechnology

Abstract

The four cyclopropyl stereoisomers of Δ7-dafachronic acids were prepared from hyodeoxycholic acid to exploit the importance of the orientation and spatial disposition of the carboxyl and the C25-methyl group for the binding at the DAF-12 receptor.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB00912E

Reference38 articles.

1. A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling

2. Small Molecule Signaling in Caenorhabditis elegans

3. Interacting genes in nematode dauer larva formation

4. Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans

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