Helix-forming aliphatic homo-δ-peptide foldamers based on the conformational restriction effects of cyclopropane-Reference-Cited by-同舟云学术

Helix-forming aliphatic homo-δ-peptide foldamers based on the conformational restriction effects of cyclopropane

Published:2023 Issue:5 Volume:21 Page:970-980
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Nagata Makoto¹,Watanabe Mizuki¹^ORCID,Doi Ryohei¹^ORCID,Uemura Mai¹,Ochiai Nanase¹,Ichinose Wataru¹,Fujiwara Koichi¹,Sato Yoshihiro¹^ORCID,Kameda Tomoshi²^ORCID,Takeuchi Koh³^ORCID,Shuto Satoshi¹^ORCID

Affiliation:

1. Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan

2. Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan

3. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

Abstract

This work reports the first aliphatic homo-δ-peptide helical foldamer consisting of a conformationally restricted δ-amino acid, where the structural characteristics of cyclopropane tightly control the backbone torsion angles.

Funder

Japan Agency for Medical Research and Development

Hokkaido University

Japan Society for the Promotion of Science

Takeda Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D2OB01715F

Reference70 articles.