Cellular Target Deconvolution of Small Molecules Using a Selection-Based Genetic Screening Platform-Reference-Cited by-同舟云学术

Cellular Target Deconvolution of Small Molecules Using a Selection-Based Genetic Screening Platform

Published:2022-09-22 Issue:10 Volume:8 Page:1424-1434
ISSN:2374-7943
Container-title:ACS Central Science
language:en
Short-container-title:ACS Cent. Sci.

Author:

Zhao Junxing¹,Tang Zhichao¹,Selvaraju Manikandan¹,Johnson Kristen A.²,Douglas Justin T.³,Gao Philip F.⁴,Petrassi H. Michael²,Wang Michael Zhuo⁵^ORCID,Wang Jingxin¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66047, United States

2. Calibr, Scripps Research Institute, La Jolla, California 92037, United States

3. Nuclear Magnetic Resonance Laboratory, University of Kansas, Lawrence, Kansas 66047, United States

4. Protein Production Group, University of Kansas, Lawrence, Kansas 66047, United States

5. Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047, United States

Funder

University of Kansas

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscentsci.2c00609

Reference58 articles.

1. Driving Drug Discovery: The Fundamental Role of Academic Labs

2. Know your target, know your molecule

3. Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

4. Target identification and mechanism of action in chemical biology and drug discovery

5. Target deconvolution strategies in drug discovery

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