Structural Evaluations of a Selective Human STING<sup>A230</sup> Agonist and Its Use in Macrophage Immunotherapies-Reference-Cited by-同舟云学术

Structural Evaluations of a Selective Human STING^A230 Agonist and Its Use in Macrophage Immunotherapies

Published:2024-04-12 Issue:5 Volume:15 Page:653-658
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Tang Zhichao¹,Zhao Junxing¹,Li Ying²,Tomer Shallu³,Selvaraju Manikandan¹,Tien Nicholas³,Sun Diyun²^ORCID,Johnson David K.⁴^ORCID,Zhen Anjie³,Li Pingwei²,Wang Jingxin¹

Affiliation:

1. Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66047, United States

2. Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, United States

3. Division of Hematology/Oncology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, United States

4. Computation Chemical Biology Core and Molecular Graphics and Modeling Laboratory, University of Kansas, Lawrence, Kansas 66047, United States

Funder

Welch Foundation

McCarthy Family Foundation

James B. Pendleton Charitable Trust

University of California

University of Kansas

U.S. Department of Health and Human Services

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.4c00048

Reference29 articles.

1. Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

2. Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

3. STING is a direct innate immune sensor of cyclic di-GMP

4. Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity

5. An orally available non-nucleotide STING agonist with antitumor activity