Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036-Reference-Cited by-同舟云学术

Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036

Published:2023-05-10 Issue:19 Volume:25 Page:3417-3422
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Xu Jie¹^ORCID,Lim Ngiap-Kie¹^ORCID,Timmerman Jacob C.¹^ORCID,Shen Jeff¹,Clagg Kyle¹^ORCID,Orcel Ugo²,Bigler Raphael²,Trachsel Etienne²,Meier Roland³,White Nicholas A.¹^ORCID,Burkhard Johannes A.¹,Sirois Lauren E.¹^ORCID,Tian Qingping¹,Angelaud Remy¹,Bachmann Stephan²,Zhang Haiming¹^ORCID,Gosselin Francis¹^ORCID

Affiliation:

1. Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. Department of Process Chemistry and Catalysis, F. Hoffmann-La Roche Ltd, Basel 4070, Switzerland

3. Department of Solid State Sciences, F. Hoffmann-La Roche Ltd, Basel 4070, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.3c00961

Reference26 articles.

1. A Comprehensive Survey of Ras Mutations in Cancer