KRasG12C inhibitors in clinical trials: a short historical perspective-Reference-Cited by-同舟云学术

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KRasG12C inhibitors in clinical trials: a short historical perspective

Published:2020 Issue:7 Volume:11 Page:760-770
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Goebel Lisa¹²³⁴⁵,Müller Matthias P.¹²³⁴⁵^ORCID,Goody Roger S.⁶⁷³⁴,Rauh Daniel¹²³⁴⁵^ORCID

Affiliation:

1. Faculty of Chemistry and Chemical Biology

2. TU Dortmund University

3. 44227 Dortmund

4. Germany

5. Drug Discovery Hub Dortmund (DDHD) am Zentrum für integrierte Wirkstoffforschung (ZIW)

6. Department of Structural Biochemistry

7. Max Planck Institute of Molecular Physiology

Abstract

Short historical perspective of the development of promising KRasG12C inhibitors that have recently entered clinical trials.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/D0MD00096E

Reference36 articles.

1. Drugging the undruggable RAS: Mission Possible?

2. The Guanine Nucleotide-Binding Switch in Three Dimensions

3. RAS isoforms and mutations in cancer at a glance

4. The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

5. Allosteric modulation of Ras positions Q61 for a direct role in catalysis

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