Fit-for-Purpose Synthesis of a KRAS<sup>G12C</sup> Covalent Inhibitor, via a Diastereoselective Hayashi Arylation-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Fit-for-Purpose Synthesis of a KRAS^G12C Covalent Inhibitor, via a Diastereoselective Hayashi Arylation

Published:2024-07-22 Issue:8 Volume:28 Page:3313-3325
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Molinaro Carmela¹^ORCID,Wong Nicholas¹^ORCID,White Nicholas A.¹^ORCID,Sirois Lauren E.¹^ORCID,Bigler Raphael²,Bindschaedler Quentin P.²^ORCID,Do Steven³,Malhotra Sushant³,Gosselin Francis¹^ORCID

Affiliation:

1. Department of Synthetic Molecule Process Chemistry, Genentech USA, Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. Department of Process Chemistry & Catalysis, Synthetic Molecules Technical Development, F. Hoffmann-La Roche AG, Grenzacherstrasse 124, CH-4070 Basel, Switzerland

3. Department of Discovery Chemistry, Genentech USA, Inc., 1 DNA Way, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.4c00211

Reference75 articles.

1. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

2. Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

3. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

4. Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors

5. Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRAS^G12C Inhibitor

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP