Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A “Bottom-Up” Approach-Reference-Cited by-同舟云学术

Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A “Bottom-Up” Approach

Published:2021-06-29 Issue:14 Volume:23 Page:5400-5404
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Paymode Dinesh J.¹^ORCID,Chang Le²,Chen Dan²,Wang Binglin²,Kashinath Komirishetty¹,Gopalsamuthiram Vijayagopal¹,McQuade D. Tyler¹^ORCID,Vasudevan N.¹,Ahmad Saeed¹,Snead David R.¹^ORCID

Affiliation:

1. Medicines for All Institute, 737 North Fifth Street, Box 980100, Richmond, Virginia 23298, United States

2. WuXi AppTec (Wuhan) Co. Ltd., Wuhan East Lake High-tech Development Zone, Wuhan 430075, P. R. of China

Funder

Bill and Melinda Gates Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.1c01725

Reference31 articles.

1. 3,5-Diaryl-2-aminopyridines as a Novel Class of Orally Active Antimalarials Demonstrating Single Dose Cure in Mice and Clinical Candidate Potential

2. Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

3. A Phase 1, Placebo-controlled, Randomized, Single Ascending Dose Study and a Volunteer Infection Study to Characterize the Safety, Pharmacokinetics, and Antimalarial Activity of the Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048

4. Safety, Tolerability, Pharmacokinetics, and Antimalarial Activity of the Novel Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048 in Healthy Volunteers

5. Structure–Activity Relationship Studies of Orally Active Antimalarial 3,5-Substituted 2-Aminopyridines

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