Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

Author:

Paquet Tanya1ORCID,Le Manach Claire1,Cabrera Diego González1,Younis Yassir1,Henrich Philipp P.23,Abraham Tara S.24ORCID,Lee Marcus C. S.25,Basak Rajshekhar26ORCID,Ghidelli-Disse Sonja7,Lafuente-Monasterio María José8,Bantscheff Marcus7,Ruecker Andrea9ORCID,Blagborough Andrew M.9,Zakutansky Sara E.9,Zeeman Anne-Marie10,White Karen L.11,Shackleford David M.11,Mannila Janne1112,Morizzi Julia11,Scheurer Christian1314,Angulo-Barturen Iñigo8,Martínez María Santos8ORCID,Ferrer Santiago8,Sanz Laura María8,Gamo Francisco Javier8,Reader Janette15,Botha Mariette15,Dechering Koen J.16,Sauerwein Robert W.1617ORCID,Tungtaeng Anchalee18,Vanachayangkul Pattaraporn19,Lim Chek Shik20,Burrows Jeremy21,Witty Michael J.121,Marsh Kennan C.22,Bodenreider Christophe20,Rochford Rosemary23ORCID,Solapure Suresh M.24ORCID,Jiménez-Díaz María Belén4,Wittlin Sergio1314,Charman Susan A.11,Donini Cristina21ORCID,Campo Brice21,Birkholtz Lyn-Marie15,Hanson Kirsten K.25ORCID,Drewes Gerard7,Kocken Clemens H. M.10,Delves Michael J.9,Leroy Didier21,Fidock David A.226,Waterson David121,Street Leslie J.1ORCID,Chibale Kelly127ORCID

Affiliation:

1. Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.

2. Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.

3. The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

4. Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 1020 Locust Street, Suite 368, Philadelphia, PA 19107, USA.

5. Malaria Programme, Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.

6. Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520–8114, USA.

7. Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

8. Malaria Disease Performance Unit, Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.

9. Department of Life Sciences, Imperial College, London SW7 2AZ, UK.

10. Department of Parasitology, Biomedical Primate Research Centre, 2280 GH Rijswijk, Netherlands.

11. Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.

12. Admescope Ltd., Typpitie 1, 90620 Oulu, Finland.

13. Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland.

14. University of Basel, 4003 Basel, Switzerland.

15. Department of Biochemistry, Centre for Sustainable Malaria Control, University of Pretoria, Pretoria, South Africa.

16. TropIQ Health Sciences, Transistorweg 5, 6534 AT Nijmegen, Netherlands.

17. Radboud University Medical Center, Department of Medical Microbiology, 6500 HB Nijmegen, Netherlands.

18. Department of Veterinary Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok 10400, Thailand.

19. Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok 10400, Thailand.

20. Novartis Institute for Tropical Diseases Pte. Ltd., 10 Biopolis Road, #05-01 Chromos, Singapore 138670, Singapore.

21. Medicines for Malaria Venture, International Center Cointrin, Route de Pré-Bois 20, 1215 Geneva, Switzerland.

22. AbbVie, 1 North Waukegan Road, North Chicago, IL 60064-6104, USA.

23. Departments of Immunology and Microbiology and Environmental and Occupational Health, University of Colorado Denver, Aurora, CO 80045, USA.

24. Nagarjuna Gardens, 60 Feet Road, Sahakaranagar, Bangalore 560092, India.

25. Department of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX 78249, USA.

26. Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.

27. South African Medical Research Council Drug Discovery and Development Research Unit, and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa.

Abstract

MMV390048, a member of a new class of inhibitors of the Plasmodium phosphatidylinositol 4-kinase, shows potential for both treatment and prophylaxis.

Funder

National Institutes of Health

Wellcome Trust

Medicines for Malaria Venture

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3