A General Route to Bicyclo[1.1.1]pentanes through Photoredox Catalysis
Author:
Affiliation:
1. Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom
2. Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States
Funder
Engineering and Physical Sciences Research Council
University of Oxford
H2020 Marie Sklodowska-Curie Actions
Publisher
American Chemical Society (ACS)
Subject
Catalysis,General Chemistry
Link
http://pubs.acs.org/doi/pdf/10.1021/acscatal.9b03190
Reference58 articles.
1. Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor
2. Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor
3. Improving Nonspecific Binding and Solubility: Bicycloalkyl Groups and Cubanes as para -Phenyl Bioisosteres
4. Toward Resolving the Resveratrol Conundrum: Synthesis and in Vivo Pharmacokinetic Evaluation of BCP–Resveratrol
5. Evaluation oftert-Butyl Isosteres: Case Studies of Physicochemical and Pharmacokinetic Properties, Efficacies, and Activities
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