Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor-Reference-Cited by-同舟云学术

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Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor

Published:2016-11-28 Issue:1 Volume:8 Page:43-48
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Measom Nicholas D.¹²,Down Kenneth D.¹,Hirst David J.¹^ORCID,Jamieson Craig²,Manas Eric S.³,Patel Vipulkumar K.¹,Somers Don O.¹

Affiliation:

1. GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.

2. Department of Pure and Applied Chemistry, University of Strathclyde, Thomas Graham Building, 295 Cathedral Street, Glasgow, G1 1XL, U.K.

3. GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426-0989, United States

Funder

GlaxoSmithKline

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.6b00281

Reference50 articles.

1. Modulation of oxidative stress, inflammation, and atherosclerosis by lipoprotein-associated phospholipase A2

2. Phospholipase A2 Biochemistry

3. The phospholipase A2 superfamily and its group numbering system

4. Human plasma platelet-activating factor acetylhydrolase. Oxidatively fragmented phospholipids as substrates

5. Hydrolysis of phosphatidylcholine during LDL oxidation is mediated by platelet-activating factor acetylhydrolase.

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