Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor-Reference-Cited by-同舟云学术

Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

Published:2012-03-29 Issue:7 Volume:55 Page:3414-3424
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Stepan Antonia F.¹,Subramanyam Chakrapani¹,Efremov Ivan V.¹,Dutra Jason K.¹,O’Sullivan Theresa J.¹,DiRico Kenneth J.¹,McDonald W. Scott¹,Won Annie¹,Dorff Peter H.¹,Nolan Charles E.¹,Becker Stacey L.¹,Pustilnik Leslie R.¹,Riddell David R.¹,Kauffman Gregory W.¹,Kormos Bethany L.¹,Zhang Liming¹,Lu Yasong¹,Capetta Steven H.¹,Green Michael E.¹,Karki Kapil¹,Sibley Evelyn¹,Atchison Kevin P.¹,Hallgren Andrew J.¹,Oborski Christine E.¹,Robshaw Ashley E.¹,Sneed Blossom¹,O’Donnell Christopher J.¹

Affiliation:

1. Pfizer Worldwide Research & Development, Eastern Point Road, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300094u

Reference35 articles.

1. Alzheimer's Disease

2. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

3. Cellular mechanisms of beta -amyloid production and secretion