Conformationally Constrained Analogues of Diacylglycerol. 24. Asymmetric Synthesis of a Chiral (R)-DAG-Lactone Template as a Versatile Precursor for Highly Functionalized DAG-Lactones-Reference-Cited by-同舟云学术

Conformationally Constrained Analogues of Diacylglycerol. 24. Asymmetric Synthesis of a Chiral (R)-DAG-Lactone Template as a Versatile Precursor for Highly Functionalized DAG-Lactones

Published:2004-06-17 Issue:14 Volume:6 Page:2413-2416
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Kang Ji-Hye¹,Siddiqui Maqbool A.¹,Sigano Dina M.¹,Krajewski Krzysztof¹,Lewin Nancy E.¹,Pu Yongmei¹,Blumberg Peter M.¹,Lee Jeewoo¹,Marquez Victor E.¹

Affiliation:

1. Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute−Frederick, National Institutes of Health, Frederick, Maryland 21702, Laboratory of Cellular Carcinogenesis & Tumor Promotion, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, and Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Shinlin Dong, Kwanak-ku, Seoul 151-742, South Korea

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ol0492041

Reference11 articles.

1. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

2. Conformationally Constrained Analogues of Diacylglycerol (DAG). 16. How Much Structural Complexity Is Necessary for Recognition and High Binding Affinity to Protein Kinase C?

3. Synthetic Diacylglycerols (DAG) and DAG-Lactones as Activators of Protein Kinase C (PK-C)

4. The Transition from a Pharmacophore-Guided Approach to a Receptor-Guided Approach in the Design of Potent Protein Kinase C Ligands

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