The Transition from a Pharmacophore-Guided Approach to a Receptor-Guided Approach in the Design of Potent Protein Kinase C Ligands-Reference-Cited by-同舟云学术

The Transition from a Pharmacophore-Guided Approach to a Receptor-Guided Approach in the Design of Potent Protein Kinase C Ligands

Published:1999-05 Issue:2-3 Volume:82 Page:251-261
ISSN:0163-7258
Container-title:Pharmacology & Therapeutics
language:en
Short-container-title:Pharmacology & Therapeutics

Author:

Marquez Victor E,Nacro Kassoum,Benzaria Samira,Lee Jeewoo,Sharma Ravij,Teng Kelly,Milne George W.A,Bienfait Bruno,Wang Shaomeng,Lewin Nancy E,Blumberg Peter M

Publisher

Elsevier BV

Subject

Pharmacology (medical),Pharmacology

Reference54 articles.

1. Conformationally constrained analogues of diacylglycerol (DAG). The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C);Benzaria;Bioorg. Med. Chem. Lett.,1998

2. Inositol triphosphate and diacylglycerol as second messengers;Berridge;Biochem. J.,1984

3. Some practical considerations and applications of the National Cancer Institute in vitro anticancer drug discovery screen;Boyd;Drug Dev. Res.,1995

4. Beta 2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters;Caloca;J. Biol. Chem.,1997

5. RasGRP, a Ras guanyl nucleotide-releasing protein with calcium and diacylglycerol binding motifs;Ebinu;Science,1998

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