Dual-Step Controlled Release of Berberine Hydrochloride from the Trans-Scale Hybrids of Nanofibers and Microparticles

Author:

Zhou Jianfeng1,Dai Yelin23,Fu Junhao1,Yan Chao1,Yu Deng-Guang1ORCID,Yi Tao4

Affiliation:

1. School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China

2. Wenqi Middle School, East Jiangchuan Road 980, Shanghai 200240, China

3. High School Affiliated to Fudan University, Qingpu Campus, Longpu Road 500, Shanghai 201700, China

4. Faculty of Health Sciences and Sports, Macao Polytechnic University, Macau 999078, China

Abstract

In this nano era, nanomaterials and nanostructures are popular in developing novel functional materials. However, the combinations of materials at micro and macro scales can open new routes for developing novel trans-scale products with improved or even new functional performances. In this work, a brand-new hybrid, containing both nanofibers and microparticles, was fabricated using a sequential electrohydrodynamic atomization (EHDA) process. Firstly, the microparticles loaded with drug (berberine hydrochloride, BH) molecules in the cellulose acetate (CA) were fabricated using a solution electrospraying process. Later, these microparticles were suspended into a co-dissolved solution that contained BH and a hydrophilic polymer (polypyrrolidone, PVP) and were co-electrospun into the nanofiber/microparticle hybrids. The EHDA processes were recorded, and the resultant trans-scale products showed a typical hybrid topography, with microparticles distributed all over the nanofibers, which was demonstrated by SEM assessments. FTIR and XRD demonstrated that the components within the hybrids were presented in an amorphous state and had fine compatibility with each other. In vitro dissolution tests verified that the hybrids were able to provide the designed dual-step drug release profiles, a combination of the fast release step of BH from the hydrophilic PVP nanofibers through an erosion mechanism and the sustained release step of BH from the insoluble CA microparticles via a typical Fickian diffusion mechanism. The present protocols pave a new way for developing trans-scale functional materials.

Funder

Shanghai Natural Science Foundation

Macao Polytechnic University Research Fund

Innovation Projects for USST students

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry

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