Affiliation:
1. Department of Engineering for Innovation, University of Salento, Via Monteroni, 73100 Lecce, Italy
2. Typeone Biomaterials Srl, Via Europa 113, 73021 Calimera, Italy
Abstract
Gelatin is a highly versatile natural polymer, which is widely used in healthcare-related sectors due to its advantageous properties, such as biocompatibility, biodegradability, low-cost, and the availability of exposed chemical groups. In the biomedical field, gelatin is used also as a biomaterial for the development of drug delivery systems (DDSs) due to its applicability to several synthesis techniques. In this review, after a brief overview of its chemical and physical properties, the focus is placed on the commonly used techniques for the development of gelatin-based micro- or nano-sized DDSs. We highlight the potential of gelatin as a carrier of many types of bioactive compounds and its ability to tune and control select drugs’ release kinetics. The desolvation, nanoprecipitation, coacervation, emulsion, electrospray, and spray drying techniques are described from a methodological and mechanistic point of view, with a careful analysis of the effects of the main variable parameters on the DDSs’ properties. Lastly, the outcomes of preclinical and clinical studies involving gelatin-based DDSs are thoroughly discussed.
Funder
INAQUA-2-0—Innovazione nel settore dell’acquacoltura sostenibile, attraverso la messa a punto di nuovi sistemi a circuito chiuso per la produzione di prodotti ittici salubri e sicuri
Cited by
14 articles.
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