New Insight on the Bioactivity of Solanum aethiopicum Linn. Growing in Basilicata Region (Italy): Phytochemical Characterization, Liposomal Incorporation, and Antioxidant Effects

Author:

Faraone ImmacolataORCID,Lela LudovicaORCID,Ponticelli MariaORCID,Gorgoglione Domenico,De Biasio Filomena,Valentão PatriciaORCID,Andrade Paula B.ORCID,Vassallo AntonioORCID,Caddeo Carla,Falabella Roberto,Ostuni AngelaORCID,Milella LuigiORCID

Abstract

Food extract’s biological effect and its improvement using nanotechnologies is one of the challenges of the last and the future decades; for this reason, the antioxidant effect of scarlet eggplant extract liposomal incorporation was investigated. Scarlet eggplant (Solanum aethiopicum L.) is a member of the Solanaceae family, and it is one of the most consumed vegetables in tropical Africa and south of Italy. This study investigated the antioxidant activity and the phytochemical composition of S. aethiopicum grown in the Basilicata Region for the first time. The whole fruit, peel, and pulp were subjected to ethanolic exhaustive maceration extraction, and all extracts were investigated. The HPLC-DAD analysis revealed the presence of ten phenolic compounds, including hydroxycinnamic acids, flavanones, flavanols, and four carotenoids (one xanthophyll and three carotenes). The peel extract was the most promising, active, and the richest in specialized metabolites; hence, it was tested on HepG2 cell lines and incorporated into liposomes. The nanoincorporation enhanced the peel extract’s antioxidant activity, resulting in a reduction of the concentration used. Furthermore, the extract improved the expression of endogenous antioxidants, such as ABCG2, CAT, and NQO1, presumably through the Nrf2 pathway.

Publisher

MDPI AG

Subject

Pharmaceutical Science

Reference43 articles.

1. Analytical Methods Used in Determining Antioxidant Activity: A Review

2. Solanum aethiopicum: The Nutrient-Rich Vegetable Crop with Great Economic, Genetic Biodiversity and Pharmaceutical Potential

3. Genetic diversity and characterization of African eggplant germplasm collection;Sunseri;Afr. J. Plant Sci.,2010

4. Indagine conoscitiva della melanzana rossa di Rotonda (Solanum aethiopicicum L.) nel Parco Nazionale del Pollino;De Cristofaro;Proceedings of the Natura 2000 in Basilicata: Percorsi di Contaminazione tra Natura, Scienza, Arte e cultura Dei Luoghi,2014

5. Phenolic distribution, antioxidant activity, and enzyme inhibitory properties of eggplant ( Solanum aethiopicum ) cultivated in two different locations within Nigeria

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