Harnessing Cyanobacteria’s Bioactive Potential: A Sustainable Strategy for Antioxidant Production
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Published:2024-01-16
Issue:1
Volume:12
Page:175
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ISSN:2076-2607
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Container-title:Microorganisms
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language:en
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Short-container-title:Microorganisms
Author:
De Rosa Teresa1, Ponticelli Maria2ORCID, Teta Roberta1ORCID, Carlucci Vittorio2ORCID, Milella Luigi2ORCID, Esposito Germana1ORCID, Costantino Valeria1ORCID
Affiliation:
1. The Blue Chemistry Lab, Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Napoli, Italy 2. Department of Science, Università Degli Studi Della Basilicata, V.le dell’Ateneo Lucano 10, 85100 Potenza, Italy
Abstract
Unsaturated diacylglycerols are a class of antioxidant compounds with the potential to positively impact human health. Their ability to combat oxidative stress through radical scavenger activity underscores their significance in the context of preventive and therapeutic strategies. In this paper we highlight the role of Anabaena flos-aquae as a producer of unsaturated mono and diacylglycerols, and then demonstrate the antioxidant activity of its methanolic extract, which has as its main components a variety of acylglycerol analogues. This finding was revealed using a sustainable strategy in which the One Strain Many Compounds (OSMAC) cultivation in microscale was coupled with a bioinformatic approach to analyze a large dataset of mass spectrometry data using the molecular networking analyses. This strategy reduces time and costs, avoiding long and expensive steps of purification and obtaining informative data on the metabolic composition of the extracts. This study highlights the role of Anabaena as a sustainable and green source of novel bioactive compounds.
Funder
National Biodiversity Future Center European Marine Biological Resource Centre
Subject
Virology,Microbiology (medical),Microbiology
Reference31 articles.
1. Combined LC–MS/MS and Molecular Networking Approach Reveals New Cyanotoxins from the 2014 Cyanobacterial Bloom in Green Lake, Seattle;Teta;Environ. Sci. Technol.,2015 2. Singh, R., Parihar, P., Singh, M., Bajguz, A., Kumar, J., Singh, S., Singh, V.P., and Prasad, S.M. (2017). Uncovering Potential Applications of Cyanobacteria and Algal Metabolites in Biology, Agriculture and Medicine: Current Status and Future Prospects. Front. Microbiol., 8. 3. Guerreiro, A., Andrade, M.A., Menezes, C., Vilarinho, F., and Dias, E. (2020). Antioxidant and Cytoprotective Properties of Cyanobacteria: Potential for Biotechnological Applications. Toxins, 12. 4. Bode, H.B., Bethe, B., Höfs, R., and Zeeck, A. (2002). Big Effects from Small Changes: Possible Ways to Explore Nature’s Chemical Diversity. ChemBioChem, 3. 5. Teta, R., Esposito, G., Kundu, K., Stornaiuolo, M., Scarpato, S., Pollio, A., and Costantino, V. (2022). A Glimpse at Siderophores Production by Anabaena Flos-aquae UTEX 1444. Mar. Drugs, 20.
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