Beyond heuristics: CFD‐based novel multiparameter scale‐up for geometrically disparate bioreactors demonstrated at industrial 2kL–10kL scales
Author:
Affiliation:
1. Regeneron Ireland DAC, Raheen Business ParkLimerick Ireland
2. Thermo Fisher Scientific Inc.Logan Utah
3. Regeneron, Industrial Operations and Product SupplyRensselaer New York
Publisher
Wiley
Subject
Applied Microbiology and Biotechnology,Bioengineering,Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.27323
Reference41 articles.
1. ANSYS Inc.(2018). ANSYS user's manual [Computer software manual].
2. Deju L. Cheung S. Yeoh G. &Tu J.(2012).An assessment of mechanistic breakage and coalescence kernels in poly‐dispersed multiphase flow.In 9th International Conference on CFD in the Minerals and Process Industries(p.1‐5).
3. CFD-based compartment model for description of mixing in bioreactors
4. A Numerical Investigation of the Constant-Velocity Volute Design Approach as Applied to the Single Blade Impeller Pump
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