Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of β-Secretase (BACE1) Inhibitors-Reference-Cited by-同舟云学术

Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of β-Secretase (BACE1) Inhibitors

Published:2014-01-23 Issue:6 Volume:53 Page:1704-1708
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Werner Michael,Kuratli Christoph,Martin Rainer E.,Hochstrasser Remo,Wechsler David,Enderle Thilo,Alanine Alexander I.,Vogel Horst

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/anie.201309301/fullpdf

Reference29 articles.

1. Hit and lead generation: beyond high-throughput screening

2. Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis and Screening Platform

3. Leveraging the Advantages Offered by Microfluidics to Enhance the Drug Discovery Process

4. β-Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s Disease

5. Continuous-flow organic synthesis: a tool for the modern medicinal chemist

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