Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis and Screening Platform-Reference-Cited by-同舟云学术

Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis and Screening Platform

Published:2013-03-25 Issue:7 Volume:56 Page:3033-3047
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Desai Bimbisar¹,Dixon Karen¹,Farrant Elizabeth¹,Feng Qixing¹,Gibson Karl R.²,van Hoorn Willem P.³,Mills James²,Morgan Trevor¹,Parry David M.¹,Ramjee Manoj K.¹,Selway Christopher N.¹,Tarver Gary J.¹,Whitlock Gavin²,Wright Adrian G.¹

Affiliation:

1. Cyclofluidic Ltd, Biopark, Broadwater Road, Welwyn Garden City, AL7 3AX, U.K.

2. Sandexis LLP, Discovery Park, Sandwich, Kent CT13 9ND, U.K.

3. Accelrys Ltd, 334 Cambridge Science Park, Cambridge, CB4 0WN, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm400099d

Reference48 articles.

1. How to improve R&D productivity: the pharmaceutical industry's grand challenge

2. Can the pharmaceutical industry reduce attrition rates?

3. Quality by Design in lead optimization: a new strategy to address productivity in drug discovery

4. Drugs, leads, and drug-likeness: an analysis of some recently launched drugs

5. Is There a Difference between Leads and Drugs? A Historical Perspective

Cited by 122 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Finding the most potent compounds using active learning on molecular pairs;Beilstein Journal of Organic Chemistry;2024-08-27

2. Self-Driving Laboratories for Chemistry and Materials Science;Chemical Reviews;2024-08-13

3. The present state and challenges of active learning in drug discovery;Drug Discovery Today;2024-06

4. Benchmarking Active Learning Protocols for Ligand-Binding Affinity Prediction;Journal of Chemical Information and Modeling;2024-03-06

5. High-throughput microfluidic systems accelerated by artificial intelligence for biomedical applications;Lab on a Chip;2024